Role of preoperative SPECT/CT standardized uptake values in medication-related osteonecrosis of the jaw: a preliminary study of SPECT/CT in relation to cone-beam CT and histopathological findings of the resected bone of mandibulectomy

Abstract Background SPECT/CT has been applied for preoperative planning of MRONJ. Furthermore, the SUV using bone enabled quantitative analysis jaw lesions. This study aimed to evaluate role SUVs in MRONJ, especially relation CBCT and histopathological findings resected mandibulectomy. The preliminary was conducted on five MRONJ patients who underwent mandibulectomy after SPECT/CT. Results SUVmax SUVmean all cases (19.5 ± 5.6 5.5 0.8) were significantly higher than those right side (8.5 2.0 2.7 0.5) left (7.2 1.6 0.4), respectively. showed osteolytic sclerotic internal texture sequestrum. characteristics necrotic granulation tissue with circumference surrounded by inflammatory cells. Conclusions results indicated a difference between sides SUVs. surgical